Tom the cat and Jerry the mouse get kicked out of their home and relocate to a fancy New York hotel, where a scrappy employee named Kayla will lose her job if she can't evict Jerry before a high-class wedding at the hotel. Her solution? Hiring Tom to get rid of the pesky mouse.

A small West Virginia town is hosting the legendary Mountain Man Festival on Halloween, where throngs of costumed party goers gather for a wild night of music and mischief. But an inbred family of hillbilly cannibals kill the fun when they trick and treat themselves to a group of visiting college students.